Mapping |
Starting material framework not mapped in product. |
Starting material framework mapped incorrectly in product, with missing or mislabeled structural elements which derail synthesis attempts. |
Starting material framework mapped correctly in product, but in a manner which derails synthesis attempts. |
Starting material framework mapped correctly in product to allow for less efficient synthesis. |
Starting material framework mapped correctly in product to allow for efficient synthesis. |
Retrosynthesis |
Retrosynthesis not attempted. |
Retrosynthesis attempted, but with many functional group transformations and/or bond disconnections skipped over, resulting in an incomplete scheme. |
Retrosynthesis completed but with some errors in functional group transformations and bond disconnects which result in errors in the forward construction of the target molecule. |
Retrosynthesis completed utilizing correct functional group transformations and bond disconnects allowing for proper forward construction of target molecule, but with excess steps. |
Retrosynthesis completed utilizing correct functional group transformations and bond disconnects allowing for proper forward construction of target molecule. |
Sequencing |
Sequencing clearly not considered. |
Reactions organized improperly, resulting in major unintended complications which derail successful synthesis attempts. |
Reactions organized improperly, resulting in minor unintended complications, but generally completing synthesis successfully. |
Reactions organized improperly, resulting in additional steps required to complete synthesis successfully. |
Reactions organized in proper sequence to allow for successful synthesis. |
Reagents |
Majority of reagents missing altogether. |
The majority of reagents are inappropriate for the required transformations. |
A number of chosen reagents not optimal, but would produce some of the desired product. |
Proper reagents chosen to achieve successful transformations, but required solvents and conditions may be missing. |
Proper reagents chosen to achieve successful transformations, including solvents and conditions where appropriate. |
Protecting Groups |
When required, use of a protecting group not considered. |
When required, protecting group utilized inappropriate to withstand the required conditions. |
When required, protecting group utilized, but better or more selective option available, such that complications arise affecting overall outcome of synthesis. |
When required, appropriate protecting groups utilized, but may be inadvertently removed by subsequent reaction conditions, with premature removal not affecting successful synthesis. |
When required, appropriate protecting groups utilized, and removed properly. |